Program

	Young Researchers Symposium
10:00	Registration
	SESSION I YRS Chair: Fred Martins
11:00	Tiessler Sala, L. Universitat Autònoma de Barcelona What molecular modelling could bring in the design of chimeric streptavidin for dual gold catalysis.
11:15	Schneider, A. Institute for Biochemistry and Technical Biochemistry Accsessing Nature's terpenome via biocatalytic shape-complementary cationic cyclization cascades.
11:30	Serrano-Aparicio, N. Universitat Jaume I Human proteasome inhibitors: activity cliff within the γ-lactam-β-lactone inhibitors family.
11:45	Escayola, S. University of Girona Global and local aromaticity of (sub)phthalocyanines
12:00	Coffee Break
	SESSION II YRS Chair: Ricard López-Coll
12:15	Oppewal, T. R. University of Groningen Selection of chemically-upgraded macrocylic peptides by phage display.
12:30	González-Granda, S. University of Oviedo Synthesis of 1,2-amino alcohols, diols, and diamines through cascade approaches employing gold(I) catalysts and enzymes.
12:45	Sorgenfrei, F. A. University of Graz The influence of cosolvents on biocatalyst stability.
13:00	Santiago-Arcos, F. J. CIC biomaGUNE Exploring the co-immobilization of multi-enzyme system to scale up step-wise biotransformations.
13:15	Lunch
	SESSION III YRS Chair: Christian Curado
14:30	Klaus, C. Bielefeld University Anti-Markovnikov oxidation of unactivated, aliphatic alkenes by directed enzyme evolution.
14:45	Estévez-Gay, M. Universitat de Girona Computational Exploration and Design of new Halohydrin Dehalogenase variants.
15:00	Seeger, M. Technische Universität Braunschweig Rational Protein Design of Bacterial beta-Etherases to Identify Catalytic Key Residues.
15:15	Leveson-Gower, R. University of Groningen Iminium catalysis with artificial enzymes.
15:30	Coffee Break
	SESSION IV YRS Chair: Guillem Casadevall
15:45	Bradshaw-Allen, R. T. University of Manchester Engineering amine dehydrogenases (AMDHS) for the synthesis of vicinal amino alcohols.
16:00	Ubasart, E. Universitat de Girona Three-shell supramolecular complex enables the symmetry-mismatched chemo- and regioselective bis-functionalization of C60.
16:15	Schell, K. Universitat Stuttgart Enforcing substrate pre-folding for cyclization through alternative active site confinement.
16:30	Kinateder, T. Universität Regensburg The evolution of the histidinolphosphate phosphatase in gamma-proteobaceria.
16:45	Round Table: Women in Science - Sponsored by FPdGi
17:15	Young Research Sympossium Prizes
18:00	Welcome reception
18:45	Girona city guided tour - Sponsored by Ajuntament de Girona

08:45	Opening ceremony
	SESSION I Chair: Miquel Costas
09:00	Plenary: Ward, T. University of Basel Artificial metalloenzymes for in vivo catalysis: challenges and opportunities.
09:50	Benitez Mateos, A. I. University of Bern Spheroplast biocatalysts boost the catalytic potential of a terpene cyclase.
10:10	Calitxo, A. R. Uppsala University Gtp hydrolysis without an active site base- resolving a decades old controversy.
10:30	Keynote: Roelfes, G. University of Groningen Designer enzymes featuring abiological catalytic sites
11:00	Coffee Break
	SESSION II Chair: Sílvia Osuna
11:20	Keynote: Turner, N. Manchester Institute of Biotechnology Discovery and engineering of new multi-functional biocatalysts for organic synthesis
11:50	Gotor Fernández, V. Universidad de Oviedo. Multicatalytic one-pot stereoselective transformations. Sequential vs concurrent cascades.
12:10	Robles Martín, A. Barcelona Supercomputing Center. Rational design of petase activity in the frac pore channel: building the foundations towards pore-based nanoreactors.
12:30	Plenary: Ramos, M.J. University of Porto - Talk sponsored by SEQENS Studies on enzyme-catalysed reactions.
13:20	Lunch
	SESSION III Chair: Miquel Solà
15:20	Keynote: Rovira, C. University of Barcelona Computer simulation of new reaction mechanisms in glycosidases
15:50	Schrittwieser, J. University of Graz. Chemo-enzymatic asymmetric synthesis of di- and trisubstituted piperidines.
16:10	Maréchal, J. D. Insilichem, UAB. Updates in computational frameworks for the study of natural and artificial metalloenzymes.s
16:30	Keynote: Hauer, B. University of Stuttgart Engineering cyclase enzymes for challenging applications.
17:00	Poster Session
19:00	Poster Session

	SESSION IV Chair: Noelia Ferruz
09:00	Plenary: Flitsch, S. University of Manchester Design and implementation of de novo biosynthetic cascades.
09:50	Peccati, F. CIC bioGUNE Computational assessment of the catalytic promiscuity of a designed metalloenzyme.
10:10	Garcia-Borràs, M. Universitat de Girona Computational characterization of enzymatic reactive intermediates for the discovery and design of new biocatalytic activities.
10:30	Keynote: Kazlauskas, R. University of Minnesota How does nature make enzymes efficient?
11:00	Coffee Break
	SESSION V Chair: Sergi Ruiz-Barragán
11:30	Keynote: Schallmey, A. TU Braunschweig Phylogenetics and motif-based database mining: complementary approaches towards novel halohydrin dehalogenases
12:00	Rubini, R. University of Groningen Engineering biocatalysts by phenotypic selections
12:20	Duran, C. Universitat de Girona. Designing tryptophan synthases for stand-alone functionality.
12:40	Plenary: Sterner, R. University of Regensburg Artificial light-control of Enzyme activity and allostery
13:30	Lunch
14:45	Excursion: Dalí Theatre-Museum
19:00	Excursion: Dalí Theatre-Museum

	SESSION VI Chair: Xavi Ribas
09:00	Keynote: Mascareñas, J.L. CIQUS, Universidade de Santiago de Compostela Translating transition metal catalysis to biological environments
09:30	Hammer, S. Bielefeld University Engineered enzymes for regioselective alkylation of multidentate n-heterocyclic nucleophiles
09:50	Cañellas, M. Zymvol Biomodeling Revolutionizing the bioproduction of high-valued compounds: in silico protocol for the efficient discovery of enzymes for non-natural reactions.
10:10	Rowbotham, J. University of Manchester Meeting the challenges of heavy drug synthesis: selective biocatalytic deuteration in batch and flow
10:30	Keynote: Chica, R. University of Ottawa Ensemble-based computational design of efficient artificial enzymes
11:00	Coffee Break
	SESSION VII Chair: Anna Company
11:20	Keynote: Dr. Swiderek, K. University Jaume I Qm/mm computational studies of the proteases: towards the design of new covalent inhibitors.
11:50	Ribeiro, A. EMBL-EBI. An Automated Tool To Propose Mechanisms of Enzyme Reactions
12:10	Bunzel, A. University of Bristol De novo enzymes by design and evolution
12:30	Plenary: Hilvert, D. ETH Zurich - Talk sponsored by Chemistry Europe Design and evolution of artificial metalloenzymes
13:20	Lunch
	SESSION VIII Chair: Ram Mahato
15:20	Keynote: Kamerlin, L. Uppsala University Harnessing conformational dynamics and computational design to generate novel enzymes
15:50	Romero, E. AstraZeneca Gothenburg A novel oxidase for h2o2-generation in unspecific peroxygenase-catalyzed drug oxyfunctionalizations
16:10	López-Gallego, F. CIC biomagune Dynamic kinetic resolution of alkyl-glyceryl ethers catalyzed by an spatially organized and immobilized multi-enzyme system.
16:30	Schnepel, C. University of Manchester Biocatalytic amide synthesis using a novel thioester recycling system
16:50	Corbella, M. Uppsala Univeristy. Complex loop dynamics underpin activity, specificity and evolvability in the (βα)8 barrel enzymes of histidine and tryptophan biosynthesis
17:10	Closing ceremony
20:00	Gala Dinner. Hotel Ultonia

Check the posters list

SOCIAL PROGRAM

Dalí Theatre-Museum | 2nd June - Included in registration

There will be coach service to get to the Museum.
Meeting point: Conference venue
Meeting time: 3 pm

Find more information on the Social Program here.

Gala Dinner | 3rd June 20:00 - Included in registration
Hotel Ultonia
20:00 Welcome at the terrace
20:30 Dinner